Vogt M, Lüthy R, Oelz O, Ferber T, Bettex J D, Joller H, Joller P, Frick P, Siegenthaler W
Schweiz Med Wochenschr. 1984 Sep 29;114(39):1314-26.
Observations of 12 patients with AIDS at this institution from March 1981 to April 1984 are reported. Ten patients were homosexuals and two were bisexual. The majority had travelled abroad (USA, Haiti) and reported multiple anonymous sexual contracts. Eleven patients reported symptoms and signs, of 2-12 months' duration, frequently seen in pre-AIDS: fatigue (10), weight loss (10), diarrhea (7), night sweats (5), fever (4), and generalized lymphadenopathy (1). Laboratory studies showed anemia (10), lymphopenia (9), leukopenia (7), decreased T-helper/T-suppressor ratio (10) and cutaneous anergy to multiple skin-test antigens (9). P. carinii pneumonia was diagnosed in three patients, P. carinii pneumonia and Kaposi's sarcoma in one patient and Kaposi's sarcoma in six patients. Another patient had a chronic mucocutaneous infection with herpes simplex and another an intestinal cryptosporidiosis and Kaposi's sarcoma. Alpha-A-interferon was used to treat patients with Kaposi's sarcoma and three patients with limited disease showed a favorable response. Six patients with advanced disease died.
报告了1981年3月至1984年4月在本机构对12例艾滋病患者的观察情况。10例患者为同性恋者，2例为双性恋者。大多数患者曾出国（美国、海地）旅行，并报告有多次匿名性接触史。11例患者报告了持续2至12个月的症状和体征，这些症状和体征在艾滋病前期较为常见：疲劳（10例）、体重减轻（10例）、腹泻（7例）、盗汗（5例）、发热（4例）和全身淋巴结肿大（1例）。实验室检查显示贫血（10例）、淋巴细胞减少（9例）、白细胞减少（7例）、辅助性T细胞/抑制性T细胞比值降低（10例）以及对多种皮肤试验抗原皮肤无反应（9例）。3例患者被诊断为卡氏肺孢子虫肺炎，1例患者同时患有卡氏肺孢子虫肺炎和卡波西肉瘤，6例患者患有卡波西肉瘤。另1例患者患有单纯疱疹慢性黏膜皮肤感染，还有1例患者患有肠道隐孢子虫病和卡波西肉瘤。α - A干扰素用于治疗卡波西肉瘤患者，3例病情较轻的患者显示出良好的反应。6例病情严重的患者死亡。
