Cassinelli G, Grein A, Masi P, Suarato A, Bernardi L, Arcamone F, Di Marco A, Casazza A M, Pratesi G, Soranzo C
J Antibiot (Tokyo). 1978 Mar;31(3):178-84. doi: 10.7164/antibiotics.31.178.
A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by application of spectroscopic methods and chemical degradation. A new synthesis of 4-O-demethyl-daunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also reported.
