13-脱氧卡马霉素，一种新的生物合成蒽环类抗生素。
13-Deoxycarminomycin, a new biosynthetic anthracycline.
作者信息
Cassinelli G, Forenza S, Rivola G, Arcamone F, Grein A, Merli S, Casazza A M
出版信息
J Nat Prod. 1985 May-Jun;48(3):435-9. doi: 10.1021/np50039a011.
PMID:3861771
Abstract
A new antitumor antibiotic, 13-deoxycarminomycin, has been isolated from the anthracycline complex produced by Streptomyces peucetius var. carminatus (ATCC 31502), a biochemical mutant of Streptomyces peucetius var. caesius, the doxorubicin-producing microorganism. The new anthracycline, showing antibacterial and cytotoxic activity in vitro, was found active against P-388 murine leukemia.
摘要
一种新的抗肿瘤抗生素——13-脱氧卡马霉素，已从产红链霉菌变种（ATCC 31502）产生的蒽环类复合物中分离出来。产红链霉菌变种是产生阿霉素的微生物——产灰链霉菌变种的生化突变体。这种新的蒽环类抗生素在体外表现出抗菌和细胞毒性活性，对P-388小鼠白血病有活性。
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