Sakaguchi A, Dohrmann G J, Mojtahedi S
Surg Neurol. 1984 Nov;22(5):527-31. doi: 10.1016/0090-3019(84)90317-3.
Experimental vasospasm was studied in a canine model utilizing subarachnoid injection of autologous blood. Alterations in the size of the basilar artery were noted angiographically. Naloxone, an opioid receptor antagonist, has been reported to have a beneficial effect on neurological dysfunction secondary to cerebral ischemia. No significant change in the diameter of the basilar artery was noted in dogs either with or without spasm when treated with naloxone. We have concluded that naloxone has no detectable vasodilatory effect on the cerebral arteries of dogs.
利用蛛网膜下腔注射自体血液的犬类模型研究了实验性血管痉挛。通过血管造影术记录基底动脉大小的变化。据报道，阿片受体拮抗剂纳洛酮对继发于脑缺血的神经功能障碍具有有益作用。在用纳洛酮治疗时，有或没有痉挛的犬类的基底动脉直径均未发现明显变化。我们得出结论，纳洛酮对犬类脑动脉没有可检测到的血管舒张作用。
