Tsimmerman Ia S, Babushkina G D
Ter Arkh. 1984;56(8):112-6.
The immunological (lymphocyte blast transformation with PHA, determination of IgA, IgM, IgG), cytochemical (the mean cytochemical index of neutrophil lipids, glycogen, peroxidase content), hematological (the leukocyte, lymphocyte and neutrophil counts), and biochemical tests were employed to study immune responsiveness in 108 patients with chronic non-calculous cholecystitis running a refractory relapsing course. The patients showed the signs of immune deficiency. Some of the above described tests turned out informative for detecting such deficiency. It has been demonstrated that conventional therapy does not provide any stable clinical effect, aggravating the manifestations of immune deficiency. The introduction into the complex of treatment measures of diphenhydramine, saparal and levamisole, in particular, favoured more rapid elimination of the clinical symptoms of a relapse, of allergic reactions, psychoemotional disorders and reduced the signs of a decrease in immune responsiveness in patients with chronic non calculous cholecystitis running a refractory relapsing course.
采用免疫学方法（用PHA进行淋巴细胞转化试验，测定IgA、IgM、IgG）、细胞化学方法（测定中性粒细胞脂质、糖原、过氧化物酶含量的平均细胞化学指数）、血液学方法（白细胞、淋巴细胞及中性粒细胞计数）和生化检测，对108例慢性非结石性胆囊炎且病程呈难治性复发的患者的免疫反应性进行研究。患者表现出免疫缺陷的迹象。上述部分检测结果对于检测此类缺陷具有参考价值。结果表明，传统疗法未产生任何稳定的临床效果，反而加重了免疫缺陷的表现。尤其是将苯海拉明、沙巴棕和左旋咪唑纳入治疗措施组合后，更有利于迅速消除复发的临床症状、过敏反应、心理情绪障碍，并减轻慢性非结石性胆囊炎且病程呈难治性复发患者免疫反应性降低的迹象。
