Winocour P D, Laimins M, Colwell J A
Thromb Haemost. 1984 Jul 29;51(3):307-12.
Platelet survival in diabetes mellitus may be decreased or normal, and it is not clear whether altered platelet survival is due to a platelet or to a non-platelet defect. Therefore, platelet survival studies were performed at intervals up to 28 days in streptozotocin-induced diabetic and normal rats, using washed platelets from diabetic or normal animals. When compared to platelets from control rats, there was a significant decrease in platelet survival when platelets from 7 and 14 day diabetic rats were injected into normal controls or into diabetic rats. After 28 days of diabetes, platelet survival in diabetic rats was significantly lengthened, whether the platelets came from control or diabetic rats. Conclusions. Shortened platelet survival in the diabetic rat is caused initially by a platelet defect. Later, non-platelet factors become dominant. These findings may help explain reported discrepancies in results of platelet survival in diabetes mellitus.
糖尿病患者的血小板存活时间可能缩短或正常，目前尚不清楚血小板存活时间的改变是由于血小板本身还是非血小板缺陷所致。因此，利用链脲佐菌素诱导的糖尿病大鼠和正常大鼠，每隔28天进行一次血小板存活研究，使用糖尿病或正常动物的洗涤血小板。与对照大鼠的血小板相比，将7天和14天糖尿病大鼠的血小板注入正常对照或糖尿病大鼠体内时，血小板存活时间显著缩短。糖尿病28天后，无论血小板来自对照大鼠还是糖尿病大鼠，糖尿病大鼠的血小板存活时间均显著延长。结论。糖尿病大鼠血小板存活时间缩短最初是由血小板缺陷引起的。后来，非血小板因素占主导地位。这些发现可能有助于解释糖尿病患者血小板存活研究结果中报道的差异。
