O'Brien J R, Etherington M D, Pashley M
Thromb Haemost. 1984 Jul 29;51(3):354-7.
Some patients with clinical evidence of atherosclerosis and others with diabetes were compared with appropriate controls. The intraplatelet level of platelet factor 4 (PF4) was significantly decreased in the arteriopaths and was lower in the diabetics when compared with controls. Patients with transient ischaemic attacks and stroke have even lower values. Intravenous heparin liberates large amounts of PF4 from an unknown reservoir, perhaps the endothelium, into the plasma. Arteriopaths liberated significantly more PF4 than the controls and the diabetics most. If a second heparin injection is given 24 hr after the first, the resultant plasma PF4 level was on average half that achieved after the first injection and again the patients had higher levels than the controls. Thus the reservoir originally "emptied" of PF4 by the heparin had been partially refilled in 24 hr and the reservoir in the atherosclerotic patients then contained more than the controls. Patients with atherosclerosis and especially diabetics differ from controls in the PF4 content of their platelets and in their response to heparin and in the rate of refill of the "heparin-mobilisable pool of PF4".
将一些有动脉粥样硬化临床证据的患者以及其他糖尿病患者与相应的对照组进行了比较。与对照组相比，动脉病患者血小板因子4（PF4）的血小板内水平显著降低，糖尿病患者的该水平更低。短暂性脑缺血发作和中风患者的值甚至更低。静脉注射肝素会从一个未知的储存库（可能是内皮）中释放大量PF4到血浆中。动脉病患者释放的PF4明显多于对照组，糖尿病患者释放的最多。如果在首次注射肝素24小时后进行第二次注射，所产生的血浆PF4水平平均为首次注射后达到水平的一半，并且患者的水平再次高于对照组。因此，最初被肝素“排空”PF4的储存库在24小时内已部分重新填充，并且动脉粥样硬化患者的储存库中的PF4含量比对照组更多。动脉粥样硬化患者，尤其是糖尿病患者，在血小板的PF4含量、对肝素的反应以及“肝素可动员的PF4池”的重新填充速率方面与对照组不同。
