Lynch D M, Leff L K, Howe S E
Thromb Haemost. 1984 Aug 31;52(1):42-4.
Three antithrombin-III assays (Sigma functional plasma, von Kaulla functional serum, and Calbiochem-Behring radial immunodiffusion) are compared using preoperative serum and plasma from 48 patients admitted for cardiovascular or other major vascular surgery. Medical records were reviewed for evidence of thrombotic complications. Eight patients (17%) in this selected population had clinical evidence of postoperative thrombotic complications. The sensitivity and specificity for each AT-III assay were calculated, and the positive and negative predictive values in this population were determined. Sigma's plasma AT-III had the highest positive predictive value (67%) and negative predictive value (100%). The functional serum and RID assays had significantly lower positive predictive values (23% and 38% respectively) and negative predictive values of 86%. Using the Two Sample t-Test to evaluate differences in AT-III values between the two patient groups, i.e., those who experienced thrombotic complications and those who did not, only the functional plasma AT-III method was statistically significant at a 95% confidence interval.
使用48例因心血管或其他大血管手术入院患者的术前血清和血浆，对三种抗凝血酶III检测方法（Sigma功能性血浆法、冯·考拉功能性血清法和Calbiochem - Behring放射免疫扩散法）进行比较。查阅病历以寻找血栓形成并发症的证据。在这个选定人群中，有8例患者（17%）有术后血栓形成并发症的临床证据。计算每种抗凝血酶III检测方法的敏感性和特异性，并确定该人群中的阳性和阴性预测值。Sigma的血浆抗凝血酶III检测方法具有最高的阳性预测值（67%）和阴性预测值（100%）。功能性血清法和放射免疫扩散检测法的阳性预测值显著较低（分别为23%和38%），阴性预测值为86%。使用两样本t检验评估两组患者（即发生血栓形成并发症的患者和未发生并发症的患者）之间抗凝血酶III值的差异，只有功能性血浆抗凝血酶III方法在95%置信区间具有统计学意义。
