Takahashi T, Iwama N
Tohoku J Exp Med. 1984 Aug;143(4):451-65. doi: 10.1620/tjem.143.451.
The basic architectural pattern of adenocarcinoma was established by 3-D reconstruction of carcinomatous glands and their lumina from serial histologic sections in four gastrectomy specimens to establish strict morphologic criteria of adenocarcinoma and related lesions on structural basis. The carcinomatous glands in the moderately differentiated type had multiple anastomoses with one another forming a 3-D network, a pattern quite different from the arborescent normal glands, whereas the lumina were separated into many small parts, giving the cell masses a porous character. Well differentiated tumor had more connections between lumina, giving rise to the formation of dense luminal network, while in the poorly differentiated variety the glands lost unity, broken up into fragmental nests. These analyses provided a new viewpoint from which to establish a basis for the discrimination of dysplastic from overtly malignant lesions.
通过对四个胃切除标本的连续组织切片中的癌性腺管及其管腔进行三维重建，建立了腺癌的基本结构模式，以便在结构基础上确立腺癌及相关病变的严格形态学标准。中分化型癌性腺管相互之间有多个吻合，形成三维网络，这一模式与树枝状的正常腺管截然不同，而管腔被分隔成许多小部分，使细胞团具有多孔特征。高分化肿瘤的管腔之间连接更多，形成密集的管腔网络，而低分化型的腺管失去整体性，分裂成碎片状巢团。这些分析提供了一个新的视角，据此可为鉴别发育异常病变与明显恶性病变奠定基础。
