Saito K, Shimoda T
Acta Pathol Jpn. 1986 Sep;36(9):1307-18. doi: 10.1111/j.1440-1827.1986.tb02851.x.
A three-dimensional analysis of the histogenesis of gastric cancer was made by examining minute, microscopic lesions of less than 500 mu. Cancer develops from the generative cell zone (G-zone) of the atrophic gastric glands and intestinal metaplastic glands. They then bud or branch and infiltrate into the propria interstitial tissue. The G-zone of the cancerous glands showed marked expansion with complete loss of normal cell kinetics of gastric glands and with hardly any signs of differentiation into pyloric glands. In the adjacent glands there were also expansion of the G-zone and formation of loop-shaped glands with abnormal branching and anastomosis sometimes leading to the formation of a network of glands. These changes are compatible with those of abnormal differentiation accompanying atrophy or intestinal metaplasia and are considered to express a preinvasive cancer.
通过检查小于500微米的微小微观病变，对胃癌的组织发生进行了三维分析。癌症起源于萎缩性胃腺和肠化生腺的生发细胞区（G区）。然后它们发芽或分支并浸润到固有间质组织中。癌性腺的G区显示出明显扩张，胃腺正常细胞动力学完全丧失，几乎没有分化为幽门腺的迹象。在相邻的腺体中，G区也有扩张，并形成环状腺体，伴有异常分支和吻合，有时会导致腺体网络的形成。这些变化与萎缩或肠化生伴随的异常分化变化一致，被认为是表达了癌前病变。
