Chevalier G, Hénin J P, Vannier H, Canevet C, Côté M G, Le Bouffant L
Toxicol Appl Pharmacol. 1984 Nov;76(2):349-55. doi: 10.1016/0041-008x(84)90016-4.
To evaluate the potential risk of pulmonary damage due to aerial spraying of the insecticide fenitrothion, rat lungs were examined under light and electron microscopy at 3, 7, 21, and 60 days after exposure. Rats were exposed by a "nose-only" apparatus for 1 hr to 2 or 500 mg/m3 of aerosolized fenitrothion (15%) mixed with solvent Cyclosol 63 (35%) and diluent oil 585 (50%). Aerosol size particles were monitored by a light scattering apparatus. Only minor modifications of lung alveolar tissues were observed after exposure to the high concentration. At 3 days, discrete foci of mild inflammation were detected, including interstitial edema, cellular infiltration, and increased number of alveolar macrophages. At 7 days, signs of irritation were diminished while at 21 and 60 days alveolar tissues were essentially normal. Exposure to lower concentration induced more limited changes at 3 days; no modifications were seen at later periods. It is concluded that a single exposure to this fenitrothion mixture at 500 mg/m3 presents no serious hazard of pulmonary toxicity.
为评估通过飞机喷洒杀螟硫磷杀虫剂导致肺部损伤的潜在风险，在暴露后的第3、7、21和60天，对大鼠肺部进行了光镜和电镜检查。通过“仅鼻吸入”装置，让大鼠暴露于与溶剂环已醇63（35%）和稀释油585（50%）混合的2或500毫克/立方米的雾化杀螟硫磷（15%）中1小时。用光散射仪监测气溶胶颗粒大小。暴露于高浓度后，仅观察到肺泡组织有轻微改变。在第3天，检测到轻度炎症的离散病灶，包括间质水肿、细胞浸润和肺泡巨噬细胞数量增加。在第7天，刺激迹象减弱，而在第21天和60天，肺泡组织基本正常。暴露于较低浓度在第3天引起的变化更有限；后期未观察到改变。结论是，单次暴露于500毫克/立方米的这种杀螟硫磷混合物不会造成严重的肺毒性危害。
