Clark C C
J Assoc Off Anal Chem. 1978 May;61(3):683-6.
Eight laboratories collaboratively studied a method for the quantitative gas-liquid chromatographic (GLC) determination of cocaine.HCl in solid forms. The cocaine.HCl and other water solubles are dissolved in dilute HCl. The aqueous solution is made weakly basic with K2HPO4, and the organic solubles are extracted into CHCl3 for the GLC determination of cocaine. Tetracosane (n-C24) is incorporated in the extracting CHCl3 as an internal standard. Five samples of known cocaine.HCl concentration and one sample of commercial ground tablets were collaboratively studied. The cocaine.HCl content ranged from 6 to 100%. Recoveries ranged from 98.7 to 103%; coefficients of variation ranged from 0.89 to 3.16. The method was adopted as official first action.
八个实验室合作研究了一种定量气液色谱（GLC）法，用于测定固体形式的可卡因盐酸盐。可卡因盐酸盐和其他水溶性物质溶解于稀盐酸中。用磷酸氢二钾将水溶液调至弱碱性，然后将有机可溶物萃取到三氯甲烷中，用于可卡因的GLC测定。正二十四烷（n-C24）作为内标物加入到萃取用的三氯甲烷中。对五个已知可卡因盐酸盐浓度的样品和一个市售磨碎片剂样品进行了合作研究。可卡因盐酸盐含量范围为6%至100%。回收率范围为98.7%至103%；变异系数范围为0.89至3.16。该方法被采用为官方首次行动方法。
