[Tissue reaction and influenza virus infectiousness during multiplication in tissue culture in the presence of remantadine].

The effect of remantadine in tissue culture of primary chick embryo fibroblasts (CEF) infected with classical fowl plague virus (FRV) was found to be dual. On the one hand, in low concentrations remantadine effectively inhibited in CEF reproduction of the virus sensitive to it. On the other, in high (subtoxic) concentrations in CEF infected with either sensitive or remantadine-resistant FPV variants it induced virus reproduction. The latter became noninfectious for normal CEF but retained its capacity for multiplication in cells treated with high concentrations of remantadine.