Demonstration of influenza virus reproduction stages sensitive to remantadine.

The antiviral action of remantadine was studied in bovine embryo kidney cells infected with influenza virus A/Victoria 35/72(H3N2-3). The drug was administered at different stages of influenza virus reproduction. Remantadine at a concentration of 50 micrograms/ml did not inhibit the activities of nuclear DNA-dependent RNA polymerase and of virion and virus-induced polymerases. Remantadine was found to inhibit the synthesis of influenza virus RNA at the stages of transcription and replication.