Rollason W N, Bennetts F E, Clarke I
Acta Anaesthesiol Scand. 1984 Oct;28(5):497-502. doi: 10.1111/j.1399-6576.1984.tb02106.x.
In a study of 120 unpremedicated outpatients presenting for outpatient dental anaesthesia, the incidence of dysrhythmias was lower with enflurane than had previously been found with halothane (1). The intravenous use of the cardioselective beta adrenergic blocking agents practolol and metoprolol, in a dose of 0.05-0.22 and 0.16-0.17 mg/kg body weight, respectively, proved effective in the treatment of sinus tachycardia in excess of 150 beats/min and/or ventricular dysrhythmias. Although metoprolol, unlike practolol, has no intrinsic sympathetic activity, there were no side-effects related to either beta-blocker in the dosages used during enflurane anaesthesia.
在一项针对120名未使用术前药的门诊牙科麻醉患者的研究中，恩氟烷导致心律失常的发生率低于先前使用氟烷时的发生率（1）。静脉注射剂量分别为0.05 - 0.22毫克/千克体重和0.16 - 0.17毫克/千克体重的心脏选择性β肾上腺素能阻滞剂心得宁和美托洛尔，被证明对治疗心率超过150次/分钟的窦性心动过速和/或室性心律失常有效。尽管美托洛尔与心得宁不同，没有内在交感活性，但在恩氟烷麻醉期间使用的剂量下，两种β受体阻滞剂均未产生副作用。
