Olofsson P, Sjöberg N O, Solum T, Svenningsen N W
Acta Obstet Gynecol Scand. 1984;63(5):467-72. doi: 10.3109/00016348409156705.
In a 21-year study covering 1960 to 1980, perinatal and infant mortality in 237 infants of diabetic mothers were analysed. The study was divided into three 7-year periods related to changes in management. In period I (1960-66) the perinatal mortality was 24.3%, decreasing to 5.0% in period II (1967-73) and to 1.1% in period III (1974-80). The corresponding figures for infant mortality were 31.4%, 7.5% and 4.6% respectively. Today the difference between the perinatal mortality rate in diabetic vs. non-diabetic pregnancies is almost negligible. However, perinatal mortality may give a false impression of pregnancy outcome, since owing to the high rate of lethal malformations in period III, infant mortality was still twice that of the non-diabetic population. During the 21-year period studied, complications of diabetic pregnancies such as severity and duration according to the White classification, hypertension and pyelonephritis in pregnancy and preterm delivery all decreased. Consequently the influence of these complicating factors on the overall outcome of diabetic pregnancies has declined.
在一项涵盖1960年至1980年的21年研究中，对237名糖尿病母亲的围产期和婴儿死亡率进行了分析。该研究根据管理变化分为三个7年时间段。在第一阶段（1960 - 1966年），围产期死亡率为24.3%，在第二阶段（1967 - 1973年）降至5.0%，在第三阶段（1974 - 1980年）降至1.1%。婴儿死亡率的相应数字分别为31.4%、7.5%和4.6%。如今，糖尿病妊娠与非糖尿病妊娠的围产期死亡率差异几乎可以忽略不计。然而，围产期死亡率可能会给妊娠结局带来错误印象，因为在第三阶段由于致命畸形的高发生率，婴儿死亡率仍是非糖尿病人群的两倍。在研究的21年期间，糖尿病妊娠的并发症，如根据怀特分类法的严重程度和持续时间、妊娠高血压和肾盂肾炎以及早产均有所减少。因此，这些复杂因素对糖尿病妊娠总体结局的影响已经下降。
