Holm H A, Abildgaard U, Kalvenes S, Anderssen N, Anker E, Arnesen K E, Blikom D, Drivenes A
Acta Med Scand. 1984;216(3):287-93. doi: 10.1111/j.0954-6820.1984.tb03806.x.
In a prospective study, 280 patients with phlebographically proven deep venous thrombosis received intravenous heparin infusion; 224 of the patients were subjected to control phlebography after 5-8 days of treatment. Females above 70 years showed least phlebographic improvement despite similar heparin dosage and heparin activity. Heparin activity in daily drawn blood samples was determined by four different assays. Chromogenic substrate (CS) assay (Coatest heparin), activated partial thromboplastin time (Cephotest), and thrombin time with recalcified plasma (CaTT) showed weak but significant correlations with thrombus resolution judged by phlebography (p = 0.004, 0.003 and 0.018, respectively). A linear prediction equation showed that the phlebographic result was about equally influenced by the mean dose and by the result of any of the three heparin assays. Thrombin time with citrated plasma showed no correlation. CS assay and CaTT showed significantly lower mean heparin activity in patients with (n = 13) than without clinically diagnosed pulmonary embolism (p = 0.012 and 0.001, respectively).
在一项前瞻性研究中，280例经静脉造影证实患有深静脉血栓形成的患者接受了静脉肝素输注；其中224例患者在治疗5 - 8天后接受了对照静脉造影。尽管肝素剂量和肝素活性相似，但70岁以上女性的静脉造影改善最少。通过四种不同的检测方法测定每日采集血样中的肝素活性。发色底物（CS）检测（Coatest肝素）、活化部分凝血活酶时间（Cephotest）以及用重新钙化血浆测定的凝血酶时间（CaTT）与静脉造影判断的血栓溶解显示出微弱但显著的相关性（分别为p = 0.004、0.003和0.018）。一个线性预测方程表明，静脉造影结果受平均剂量和三种肝素检测中任何一种结果的影响大致相同。用枸橼酸盐血浆测定的凝血酶时间无相关性。CS检测和CaTT显示，患有临床诊断肺栓塞的患者（n = 13）的平均肝素活性显著低于未患肺栓塞的患者（分别为p = 0.012和0.001）。
