Novick A C, Straffon R A, Koshino I, Banowsky L H, Levin H, Kambic H
J Biomed Mater Res. 1978 Mar;12(2):125-47. doi: 10.1002/jbm.820120202.
A controlled canine experimental study has been performed to test the application of a biodegradeable graft to vesical augmentation. The graft, after providing initial bladder enlargement, is progressively reabsorbed while serving as a foundation for the regeneration and healing of the layers of the bladder remnant. Follow-up studies at 1 year revealed no urinary infection, calculi, extravasation of urine, or rejection of the material. Normal bladder capacities were maintained throughout the study and the reconstructed bladders functioned normally. The biodegradable graft was equally successful when applied either to a histologically normal bladder remnant, or to a pathological bladder of intramural fibrosis. These results suggest that this material may be well suited to clinical bladder substitution in humans.
已进行一项对照犬实验研究，以测试可生物降解移植物在膀胱扩大术中的应用。该移植物在使膀胱初步增大后，会逐渐被重新吸收，同时作为膀胱残余层再生和愈合的基础。1年的随访研究显示无尿路感染、结石、尿液外渗或材料排斥反应。在整个研究过程中膀胱容量保持正常，重建后的膀胱功能正常。当将这种可生物降解移植物应用于组织学正常的膀胱残余或壁内纤维化的病理性膀胱时，同样取得了成功。这些结果表明，这种材料可能非常适合人类临床膀胱替代。
