Rathi A B, Nath N, Chari S N
Acta Vitaminol Enzymol. 1984;6(2):97-102.
Possible mechanisms responsible for hepatic lysosomal fragility in hypercholesterolemic rats have been investigated. It was found that certain factor(s) present in the intracellular environment of liver were required for the release of lysosomal enzymes. Elevated hepatic dehydroascorbic acid content in hypercholesterolemic rats is thought to render the lysosomes fragile in this pathological state, since this compound was found to labilise the lysosomes in vitro. Quercetin and hesperidin were found to be responsible for lysosomal stability, probably by reducing the content of dehydroascorbic acid to a normal level in the hypercholesterolemic condition.
对高胆固醇血症大鼠肝脏溶酶体脆弱性的可能机制进行了研究。发现肝脏细胞内环境中存在的某些因素是溶酶体酶释放所必需的。高胆固醇血症大鼠肝脏脱氢抗坏血酸含量升高被认为使溶酶体在这种病理状态下变得脆弱，因为在体外发现这种化合物会使溶酶体不稳定。发现槲皮素和橙皮苷对溶酶体稳定性起作用，可能是通过在高胆固醇血症状态下将脱氢抗坏血酸含量降低到正常水平。
