Rathi A B, Nath N, Chari S N
Acta Vitaminol Enzymol. 1983;5(4):255-61.
Vitamin P like compounds such as quercetin and hesperidin administered at a dose of 50 mg/Kg/day along with a hypercholesterolemic diet for three weeks significantly restored the elevated cholesterol/phospholipid ratio in rats. Both these flavonoids exerted in vivo a stabilising effect on lysosomes in rat liver which had been rendered fragile in hypercholesterolemic condition. Moreover, these compounds also possessed the stabilisation effect on lysosomes in vitro. The stabilisation effect exerted on lysosomes was found to be due to the retarded release of lysosomal acid hydrolases and not to enzyme inhibition. Such stabilisation of the lysosomes may have a beneficial role in partial amelioration of hypercholesterolemic conditions.
诸如槲皮素和橙皮苷之类的类维生素P化合物，以50毫克/千克/天的剂量与高胆固醇饮食一起给予大鼠三周，可显著恢复大鼠升高的胆固醇/磷脂比率。这两种类黄酮在体内对高胆固醇血症条件下已变得脆弱的大鼠肝脏溶酶体具有稳定作用。此外，这些化合物在体外对溶酶体也具有稳定作用。发现对溶酶体产生的稳定作用是由于溶酶体酸性水解酶的释放延迟，而不是由于酶抑制。溶酶体的这种稳定作用可能在高胆固醇血症状况的部分改善中具有有益作用。
