Gourlay S J, Rice R M, Hegyeli A F, Wade C W, Dillon J G, Jaffe H, Kulkarni R K
J Biomed Mater Res. 1978 Mar;12(2):219-32. doi: 10.1002/jbm.820120207.
An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The methods is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.
描述了一种用于筛选聚合物材料生物相容性的体内方法。该测试基于分别在植入大鼠后7天和28天对急性和亚急性组织反应进行分级。该方法具有可重复性和可靠性。其设计目的是为手术植入材料开发早期阶段的生物相容性评估提供统一的测试标准。
