Cholst I N, Wardlaw S L, Newman C B, Frantz A G
Am J Obstet Gynecol. 1984 Nov 1;150(5 Pt 1):558-61. doi: 10.1016/s0002-9378(84)90439-3.
Several reports have shown that the prolactin response to suckling in rats can be blunted by administration of the opiate antagonist naloxone. In order to investigate whether the prolactin response to breast stimulation in women is similarly affected by naloxone, nine healthy lactating women participated in 10 studies. Each woman served as her own control and was studied on two occasions, receiving pretreatment with either saline solution or naloxone. Prolactin was measured in the baseline state and for 60 minutes after the onset of a 20-minute period of nipple stimulation by use of the Egnell mechanical breast pump. Neither baseline nor stimulated prolactin values were different by paired t test. Thus, in contrast to rats, an opioid pathway does not appear to be involved in the prolactin response to suckling in humans.
有几份报告表明，给大鼠注射阿片拮抗剂纳洛酮会减弱其对哺乳的催乳素反应。为了研究纳洛酮是否同样会影响女性对乳房刺激的催乳素反应，9名健康的哺乳期女性参与了10项研究。每位女性都作为自己的对照，在两个不同场合接受研究，分别预先注射生理盐水或纳洛酮。使用埃内尔机械吸奶器在基线状态以及乳头刺激20分钟开始后的60分钟内测量催乳素。配对t检验显示，基线和刺激后的催乳素值均无差异。因此，与大鼠不同，阿片类途径似乎并不参与人类对哺乳的催乳素反应。
