Volpi R, Chiodera P, Gramellini D, Cigarini C, Papadia C, Caffarri G, Rossi G, Coiro V
University Clinic of Internal Medicine, University of Parma, Italy.
Life Sci. 1994;54(11):739-44. doi: 10.1016/0024-3205(94)90163-5.
The effect of ethanol on the prolactin (PRL) response to breast stimulation was tested in normal women. The possible role of endogenous opioids in the control of the PRL response to breast stimulation and ethanol action was also examined. Eleven normal women were tested four times on the 22nd day of four consecutive regular menstrual cycles. All women underwent mechanical breast stimulation (for 10 min) with the concomitant administration of normal saline, naloxone (2 mg in an iv bolus plus 10 mg over 75 min. or 4 mg in an iv bolus plus 20 mg over 75 min.), ethanol (50 ml in 110 ml of whiskey p.o.) or the combination of ethanol and naloxone. Serum PRL levels rose significantly after breast stimulation, with a mean peak response (71.4% higher than baseline at 20 min). The PRL response to breast stimulation was not changed by the treatment with the lower (2 plus 10 mg) or the higher (4 plus 20 mg) dose of naloxone, whereas it was strikingly decreased by ethanol (mean peak was 25% higher than baseline). However, when ethanol was given together with naloxone, the peak rise induced by breast stimulation was only partially inhibited by ethanol (the mean PRL peak was 46.2% higher than baseline). At both doses naloxone produced similar effects. These data demonstrate that ethanol inhibits the PRL response to breast stimulation. Naloxone-sensitive endogenous opioids do not appear to be involved in the control of the PRL rise induced by breast stimulation. In contrast, since naloxone partially reversed the inhibiting effects of ethanol, a partial involvement of opioid peptides in ethanol action is supposed.
在正常女性中测试了乙醇对催乳素（PRL）对乳房刺激反应的影响。还研究了内源性阿片类物质在控制PRL对乳房刺激反应及乙醇作用中的可能作用。在四个连续正常月经周期的第22天，对11名正常女性进行了四次测试。所有女性均接受机械乳房刺激（持续10分钟），同时给予生理盐水、纳洛酮（静脉推注2毫克加75分钟内输注10毫克，或静脉推注4毫克加75分钟内输注20毫克）、乙醇（口服110毫升威士忌中含50毫升乙醇）或乙醇与纳洛酮的组合。乳房刺激后血清PRL水平显著升高，平均峰值反应（在20分钟时比基线高71.4%）。较低剂量（2加10毫克）或较高剂量（4加20毫克）的纳洛酮治疗对PRL对乳房刺激的反应没有影响，而乙醇使其显著降低（平均峰值比基线高25%）。然而，当乙醇与纳洛酮一起给药时，乳房刺激引起的峰值升高仅被乙醇部分抑制（PRL平均峰值比基线高46.2%）。两种剂量的纳洛酮产生相似的效果。这些数据表明乙醇抑制PRL对乳房刺激的反应。纳洛酮敏感的内源性阿片类物质似乎不参与控制乳房刺激引起的PRL升高。相反，由于纳洛酮部分逆转了乙醇的抑制作用，推测阿片肽部分参与了乙醇的作用。
