Tulandi T, Kinch R A, Guyda H, Mazella L, Lal S
Am J Obstet Gynecol. 1984 Nov 15;150(6):709-12. doi: 10.1016/0002-9378(84)90672-0.
The effect of methyldopa (100 mg intravenously), the precursor of the alpha-receptor agonist alpha-methylnorepinephrine, on subjectively experienced menopausal flushes, skin temperature, and luteinizing hormone secretion was investigated in seven women in a double-blind, saline-controlled, crossover study. Subjects were monitored over a 3-hour period. Methyldopa significantly decreased the number of subjective flushes (p less than 0.05) and the number of cutaneous temperature peaks (p less than 0.05) but had no effect on the number of luteinizing hormone secretory pulses, variability of luteinizing hormone secretion, or total luteinizing hormone secretion. These studies indicate that alpha-adrenergic mechanisms (central and/or peripheral) play a role in the pathophysiology of menopausal flushes.
在一项双盲、生理盐水对照的交叉研究中，对7名女性研究了α受体激动剂α-甲基去甲肾上腺素的前体甲基多巴（静脉注射100毫克）对主观感受到的潮热、皮肤温度和促黄体生成素分泌的影响。在3小时内对受试者进行监测。甲基多巴显著减少了主观潮热的次数（p<0.05）和皮肤温度峰值的次数（p<0.05），但对促黄体生成素分泌脉冲的次数、促黄体生成素分泌的变异性或促黄体生成素的总分泌量没有影响。这些研究表明，α-肾上腺素能机制（中枢和/或外周）在绝经潮热的病理生理学中起作用。
