Andersen O, Engebretsen T, Solberg V M, Orbo A
Acta Obstet Gynecol Scand. 1986;65(5):405-9. doi: 10.3109/00016348609157373.
The effects of single evening doses of alpha-methyldopa and placebo have been compared in 40 women with climacteric hot flushes. The study was designed as a double-blind, randomized and cross-over investigation. Of the 24 patients who completed the study, 15 reported that they preferred the alpha-methyldopa treatment (p greater than 0.05). alpha-methyldopa seemed to affect both the severity (p less than 0.05) and the frequency of climacteric hot flushes (p greater than 0.05). It is concluded that alpha-methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.
已对40名患有更年期潮热的女性单次晚间服用α-甲基多巴和安慰剂的效果进行了比较。该研究设计为双盲、随机和交叉调查。在完成研究的24名患者中，15名报告更喜欢α-甲基多巴治疗（p>0.05）。α-甲基多巴似乎对更年期潮热的严重程度（p<0.05）和频率（p>0.05）均有影响。得出的结论是，α-甲基多巴单次晚间给药对更年期潮热有效，但需要进一步研究以确定该剂量是否与每日两次给药方案一样有效。
