Block B S, Liggins G C, Creasy R K
Am J Obstet Gynecol. 1984 Nov 15;150(6):716-22. doi: 10.1016/0002-9378(84)90674-4.
Previous studies suggest that plasma estradiol-17 beta and progesterone concentration values differ between patients who deliver before term and those who deliver at term. To determine if these values would aid in preterm delivery risk prediction, we measured plasma estradiol-17 beta and progesterone concentrations serially in 90 patients at high risk for preterm delivery. Measurements from 17 patients who developed documented preterm labor and/or were delivered before term were compared to the tenth and ninetieth percentiles of 42 patients who were delivered at term. The sensitivity of these measurements to predict preterm delivery was very low. Also, the mean plasma estradiol-17 beta and progesterone concentrations in patients with preterm labor who had term deliveries and in patients with preterm labor that progressed to preterm delivery were not different from each other or from patients delivering at term. No change in plasma estradiol-17 beta or progesterone concentration was noted preceding labor. We conclude that serial measurements of plasma estradiol-17 beta and progesterone concentrations do not improve preterm delivery risk prediction.
先前的研究表明，早产患者与足月分娩患者的血浆雌二醇-17β和孕酮浓度值存在差异。为了确定这些值是否有助于预测早产风险，我们对90名早产高危患者连续测量了血浆雌二醇-17β和孕酮浓度。将17例发生早产并有记录或早产的患者的测量值与42例足月分娩患者的第十和第九十百分位数进行比较。这些测量预测早产的敏感性非常低。此外，足月分娩的早产患者和进展为早产的早产患者的血浆雌二醇-17β和孕酮平均浓度彼此之间以及与足月分娩患者之间没有差异。分娩前未发现血浆雌二醇-17β或孕酮浓度有变化。我们得出结论，连续测量血浆雌二醇-17β和孕酮浓度并不能改善早产风险预测。
