Lerner A, Lee P C, Lebenthal E
Am J Physiol. 1984 Oct;247(4 Pt 1):G346-51. doi: 10.1152/ajpgi.1984.247.4.G346.
The role of corticosterone in the development of pancreatic enzymes of suckling rats was studied through a partial and transient blockade of steroidogenesis by aminoglutethimide. Rats were injected with aminoglutethimide the night before their 14th day of age. Ten hours later they showed a transient decrease of serum total corticosterone level as compared with rats injected only with the vehicle. At 34 and 58 h after injection, their corticosterone levels returned to that of control rats. Pancreatic weight, protein, DNA contents, and total activities of amylase, lipase, and trypsinogen were depressed only in the aminoglutethimide-treated pups 34 h after injection. These pancreatic parameters returned to the control level 58 h after injection. Hydrocortisone given to another group of rats completely abolished the effect of aminoglutethimide on the pancreas. Thus, a transient suppression of serum corticosterone level caused a delay in the developmental accumulation of pancreatic exocrine enzymes that resumed only after the serum corticosterone returned to the control level. These results further confirm that corticosterone is an important modulator of pancreatic enzyme development in the rat.
通过氨鲁米特对类固醇生成进行部分和短暂的阻断，研究了皮质酮在乳鼠胰腺酶发育中的作用。在大鼠14日龄的前一晚给它们注射氨鲁米特。10小时后，与仅注射赋形剂的大鼠相比，它们的血清总皮质酮水平出现短暂下降。注射后34小时和58小时，它们的皮质酮水平恢复到对照大鼠的水平。仅在注射后34小时，氨鲁米特处理的幼崽的胰腺重量、蛋白质、DNA含量以及淀粉酶、脂肪酶和胰蛋白酶原的总活性受到抑制。这些胰腺参数在注射后58小时恢复到对照水平。给另一组大鼠注射氢化可的松完全消除了氨鲁米特对胰腺的影响。因此，血清皮质酮水平的短暂抑制导致胰腺外分泌酶发育积累延迟，这种延迟仅在血清皮质酮恢复到对照水平后才恢复。这些结果进一步证实皮质酮是大鼠胰腺酶发育的重要调节因子。
