Soma L R, Korber K, Anderson T, Hopkins J
Am J Vet Res. 1984 Sep;45(9):1743-9.
The effects of furosemide (0.55 mg/kg IV) on the plasma and urinary fentanyl (PFE UFE) concentrations were studied during steady-state conditions. The PFE during the steady-state period was 0.31 +/- 0.027 ng/ml, with no significant changes occurring, even though the rate of excretion of fentanyl (EX) increased during the 1st hour from 112.0 +/- 21.6 to 534.5 +/- 82.9 ng/minute. The EX returned to control levels within 3 hours, as did the UFE. The injection of furosemide increased glomerular filtration rate from 1.97 +/- 0.21 to 3.81 +/- 0.75 ml/kg/min. The fractional reabsorption decreased from a control of 70.3 +/- 6.2% to 25.2 +/- 2.3% during the 1st hour, returning to control levels at 3 hours after furosemide was given. The total body clearance of fentanyl increased slightly during the peak period of diuresis. The return of EX, fractional reabsorption, UFE, and clearance of endogenous creatinine to control levels occurred before the return of urine specific gravity, indicating the ability of the kidney to concentrate fentanyl before its water concentrating capacity had returned.
在稳态条件下研究了呋塞米（0.55毫克/千克静脉注射）对血浆和尿液中芬太尼浓度（PFE、UFE）的影响。稳态期的PFE为0.31±0.027纳克/毫升，尽管芬太尼排泄率（EX）在第1小时内从112.0±21.6增加到534.5±82.9纳克/分钟，但仍未发生显著变化。EX在3小时内恢复到对照水平，UFE也是如此。注射呋塞米使肾小球滤过率从1.97±0.21增加到3.81±0.75毫升/千克/分钟。第1小时内，重吸收分数从对照的70.3±6.2%降至25.2±2.3%，在给予呋塞米后3小时恢复到对照水平。在利尿高峰期，芬太尼的全身清除率略有增加。EX、重吸收分数、UFE和内源性肌酐清除率恢复到对照水平发生在尿比重恢复之前，这表明肾脏在其浓缩水的能力恢复之前就有浓缩芬太尼的能力。
