Michoud M C, Amyot R, Jeanneret-Grosjean A
Am Rev Respir Dis. 1984 Nov;130(5):755-8. doi: 10.1164/arrd.1984.130.5.755.
The effect of increasing doses of dopamine (inhaled or infused) on pulmonary resistance (RL) was measured in 4 normal and in 4 asthmatic subjects. Dopamine, in doses sufficient to raise systolic blood pressure 25 mmHg, did not change RL. However, dopamine, inhaled and infused, significantly decreased histamine-induced bronchoconstriction both in normal and in asthmatic subjects. Thus, we conclude that if dopamine is released by the adrenal medulla during an asthmatic attack, it should have a beneficial rather than a deleterious effect.
在4名正常人和4名哮喘患者中测量了递增剂量的多巴胺（吸入或静脉输注）对肺阻力（RL）的影响。多巴胺剂量足以使收缩压升高25 mmHg时，并未改变肺阻力。然而，吸入和静脉输注的多巴胺均能显著减轻正常人和哮喘患者中组胺诱导的支气管收缩。因此，我们得出结论，如果在哮喘发作期间肾上腺髓质释放多巴胺，它应产生有益而非有害的作用。
