体育运动和牛饲料中合成代谢药物滥用的调查。II. 尿液中纳克量美雄酮（大力补）的特异性测定。
Investigations of anabolic drug abuse in athletics and cattle feed. II. Specific determination of methandienone (Dianabol) in urine in nanogram amounts.
作者信息
Frischkorn C G, Frischkorn H E
出版信息
J Chromatogr. 1978 Apr 21;151(3):331-8. doi: 10.1016/s0021-9673(00)88348-x.
A high-performance liquid chromatographic method for the determination of the free excreted anabolic drug methandienone in pharmacokinetic studies is described. After extraction of the free steroids from urine, separation on reversed-phase columns leads to quantitative determination of this drug down to 5 ng, and to qualitative detection of less than 1 ng amounts. Because the anabolic drugs and their metabolites are eluted later than the other normally excreted constituents this method is also useful for the routine surveillance of anabolic drug abuse in the sports in general.
描述了一种用于药代动力学研究中测定游离排泄的合成代谢药物美雄酮的高效液相色谱法。从尿液中提取游离类固醇后，在反相柱上进行分离可对该药物进行低至5纳克的定量测定，并可对低于1纳克量进行定性检测。由于合成代谢药物及其代谢物的洗脱时间晚于其他正常排泄成分，因此该方法通常也可用于体育界合成代谢药物滥用的常规监测。
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