Nakaya H, Ozaki S, Kimura S, Gotoh Y, Kanno M
Arch Int Pharmacodyn Ther. 1984 Jul;270(1):88-96.
Lysophosphoglycerides such as lysophosphotidylcholine (LPC) have been shown to accumulate in ischemic myocardium and may be important in the genesis of arrhythmias. In this study effects of verapamil on electrophysiological and biochemical derangements induced by LPC were evaluated in Langendorff-perfused rabbit hearts. LPC perfusion (10 microM) produced conduction disturbances and enhanced spontaneous firing concomitantly with increasing potassium and creatine phosphokinase contents in the coronary effluents. Although pretreatment with verapamil (2 microM) did not show any significant effects on the conduction delay and biochemical changes, it suppressed the occurrence of rapid spontaneous firing during LPC perfusion. These results suggest that relatively low concentration of LPC can induce electrophysiological and biochemical derangements comparable to those observed during myocardial ischemia and that verapamil may modify the dysrhythmias induced by LPC.
溶血磷脂甘油酯，如溶血磷脂酰胆碱（LPC），已被证明会在缺血心肌中蓄积，并且可能在心律失常的发生中起重要作用。在本研究中，在Langendorff灌注兔心脏中评估了维拉帕米对LPC诱导的电生理和生化紊乱的影响。LPC灌注（10微摩尔）产生传导障碍，并增强自发放电，同时冠状动脉流出液中的钾和肌酸磷酸激酶含量增加。虽然用维拉帕米（2微摩尔）预处理对传导延迟和生化变化没有显示出任何显著影响，但它抑制了LPC灌注期间快速自发放电的发生。这些结果表明，相对低浓度的LPC可诱导与心肌缺血期间观察到的电生理和生化紊乱相当的紊乱，并且维拉帕米可能会改变由LPC诱导的心律失常。
