Cameron O G, Kronfol Z, Greden J F, Carroll B J
Arch Gen Psychiatry. 1984 Nov;41(11):1090-5. doi: 10.1001/archpsyc.1983.01790220080013.
Several clinical and physiologic associations between depression and diabetes mellitus have been reported. In this study, a potential neuroendocrine association was studied by measuring hypothalamic-pituitary-adrenocortical (HPA) axis activity in patients with diabetes mellitus. Plasma cortisol levels and response to dexamethasone administration were determined in 54 diabetics. Twenty-three (55%) of forty-two 1-mg dexamethasone suppression tests (DSTs) performed in 34 subjects, with eight repeated tests, and two (10%) of twenty 2-mg DSTs demonstrated a blunting of normal suppression. None of a variety of potential demographic, physiologic, or mood factors predicted nonsuppression. This study replicates prior findings that HPA dysfunction occurs in association with diabetes, and invalidates the use of the 1-mg DST as a diagnostic marker for melancholia in patients with diabetes.
已有多项研究报道了抑郁症与糖尿病之间的一些临床及生理联系。在本研究中，通过测量糖尿病患者下丘脑 - 垂体 - 肾上腺皮质（HPA）轴的活性，对一种潜在的神经内分泌联系进行了研究。测定了54名糖尿病患者的血浆皮质醇水平以及对地塞米松给药的反应。在34名受试者中进行了42次1毫克地塞米松抑制试验（DST），其中23次（55%），包括8次重复试验，以及20次2毫克DST中的2次（10%）显示正常抑制反应减弱。各种潜在的人口统计学、生理学或情绪因素均无法预测抑制反应缺失。本研究重复了先前的发现，即HPA功能障碍与糖尿病相关，并证明1毫克DST不能作为糖尿病患者忧郁症的诊断标志物。
