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劳舍尔白血病中与D-半乳糖基残基的短暂暴露相关的脾细胞免疫原性。

Immunogenicity of splenocytes, associated with temporal exposition of D-galactosyl residues, in Rauscher leukemia.

作者信息

Novichenko N L

出版信息

Arch Geschwulstforsch. 1984;54(4):279-84.

PMID:6497576
Abstract

To prove the existance of specific cellular immunity in leukemia the antigen preparations, obtained from the leukemia spleens and from embryos were studied in electrophoretic mobility test. It was shown that only spleens, which were obtained at days 2 and 3 after virus inoculation, possess the specific antigenic activity. Immunogenicity is associated with D-galactosyl residues, as was shown in the experiments with competitive inhibition by sugars, binding with peanut lectin and isolation of PNL-positive cells.

摘要

为了证明白血病中特异性细胞免疫的存在,对从白血病脾脏和胚胎中获得的抗原制剂进行了电泳迁移率试验研究。结果表明,只有在病毒接种后第2天和第3天获得的脾脏具有特异性抗原活性。如糖类竞争抑制实验、与花生凝集素结合实验以及PNL阳性细胞分离实验所示,免疫原性与D-半乳糖基残基有关。

相似文献

1
Immunogenicity of splenocytes, associated with temporal exposition of D-galactosyl residues, in Rauscher leukemia.劳舍尔白血病中与D-半乳糖基残基的短暂暴露相关的脾细胞免疫原性。
Arch Geschwulstforsch. 1984;54(4):279-84.
2
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