Katenkamp D, Berndt R, Perevoshchikov A, Raikhlin N T
Arch Geschwulstforsch. 1984;54(4):301-8.
The stroma of 18 human colon carcinomas was studied with regard to the occurrence of myofibroblasts. In addition, we tried to determine if there was any relationship between myofibroblasts and other stromal responses to tumor growth, e.g. immunologic inflammatory reactions or activation of vascular structures. We found myofibroblasts in 13 carcinomas, although only sporadically in 6 of them. In 5 carcinomas these cells were absent. The number of myofibroblasts showed an inverse relation to the quantity of inflammatory cells (mainly lymphocytes, plasma cells and histiocytes). A variable amount of activated vascular structures could be seen in all cases. In 5 tumors many activated vessels showed a multilayered basement membrane. The electron microscopic findings led to the conclusions that myofibroblast proliferation and immunologic inflammation are not positively correlated with each other and that vascular activation does not parallel myofibroblast induction. The significance of the individual components for tumor prognosis is briefly discussed and the need for further work to clarify the role and mode of interaction of the different factors in tumor-induced stromal response is emphasized.
我们研究了18例人类结肠癌的基质中肌成纤维细胞的发生情况。此外，我们试图确定肌成纤维细胞与肿瘤生长的其他基质反应之间是否存在任何关系，例如免疫炎症反应或血管结构的激活。我们在13例癌组织中发现了肌成纤维细胞，不过其中只有6例是散在分布的。在5例癌组织中未发现这些细胞。肌成纤维细胞的数量与炎症细胞（主要是淋巴细胞、浆细胞和组织细胞）的数量呈负相关。在所有病例中都可见到数量不等的激活血管结构。在5个肿瘤中，许多激活的血管显示出多层基底膜。电镜检查结果得出以下结论：肌成纤维细胞增殖与免疫炎症之间不存在正相关，血管激活与肌成纤维细胞诱导也不平行。文中简要讨论了各个成分对肿瘤预后的意义，并强调需要进一步开展工作以阐明不同因素在肿瘤诱导的基质反应中的作用和相互作用方式。
