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[可移植性詹森肉瘤、环磷酰胺和长春碱、丁酸梭菌M55治疗试验及短期高血糖对白化大鼠某些白细胞功能的影响]

[Modification of selected leukocyte functions in albino rats caused by the transplantable Jensen sarcoma and by therapeutic trials of cyclophosphamide and vinblastine, Clostridium butyricum M55 and short-term hyperglycemia].

作者信息

Hambsch K, Henke R, Ludewig R

出版信息

Arch Geschwulstforsch. 1984;54(5):369-76.

PMID:6497582
Abstract

A significant increase in leukocyte adhesion and agglomeration was observed in white rats with Jensen sarcoma. Glucose induced short-term hyperglycemia temporarily stimulated these leukocyte functions in healthy rats. This effect was not notably influenced by administration of tumorlyzing spores. In contrast administration of the cytostatic agents vinblastine and cyclophosphamide demonstrated dose-related inhibition of leukocyte agglomeration and adhesion.

摘要

在患有詹森肉瘤的白鼠中观察到白细胞黏附和聚集显著增加。葡萄糖诱导的短期高血糖症在健康大鼠中暂时刺激了这些白细胞功能。这种效应并未受到溶瘤孢子给药的显著影响。相比之下,细胞抑制剂长春碱和环磷酰胺的给药显示出与剂量相关的白细胞聚集和黏附抑制作用。

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