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[大鼠肿瘤放射治疗期间甲硝唑与短期高血糖的联合应用]

[Combined use of metronidazole and short-term hyperglycemia during radiation therapy of tumors in rats].

作者信息

Vepkhvadze N R, Iarmonenko S P

出版信息

Radiobiologiia. 1985 May-Jun;25(3):333-7.

PMID:4023185
Abstract

A simultaneous combined treatment with metronidazole and short-term hyperglycaemia, in contrast to application of each of these agents alone, enhanced considerably the therapeutic effect of radiation (a single and fractionated exposure). This was indicated by the increased rate of tumor regression, the number of animals with transient remission, and the number of cured animals which exhibited no relapse throughout the entire 90-day period of observation.

摘要

与单独使用甲硝唑或短期高血糖治疗相比,甲硝唑与短期高血糖联合治疗可显著增强放疗(单次和分次照射)的治疗效果。这表现为肿瘤消退率提高、出现短暂缓解的动物数量增加以及在整个90天观察期内无复发的治愈动物数量增加。

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Radiobiologiia. 1985 May-Jun;25(3):333-7.
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