Leigh D A, Simmons K
J Clin Pathol. 1978 May;31(5):439-43. doi: 10.1136/jcp.31.5.439.
Bacterial counts were carried out on the faeces of 160 patients receiving clindamycin or lincomycin treatment for bacterial infections. In all the patients the total bacteroides count was significantly reduced while strains of Enterobacteriaciae, yeasts, and streptococci were correspondingly increased. Severe diarrhoea developed in 25 (16%) patients, but this could not be related to a change in faecal flora. Diarrhoea was most common when clindamycin was given prophylactically, women were more affected than men, and the incidence was highest in those aged over 60 years. No cases of pseudomembranous colitis were seen. Although clindamycin is a valuable antibiotic for treating established severe anaerobic bacterial infections it should be used cautiously in elderly patients.
对160例因细菌感染接受克林霉素或林可霉素治疗的患者的粪便进行了细菌计数。在所有患者中，拟杆菌总数显著减少，而肠杆菌科细菌、酵母菌和链球菌菌株相应增加。25例（16%）患者出现严重腹泻，但这与粪便菌群变化无关。腹泻在预防性使用克林霉素时最为常见，女性比男性受影响更大，60岁以上患者的发病率最高。未观察到假膜性结肠炎病例。虽然克林霉素是治疗已确诊的严重厌氧细菌感染的一种有价值的抗生素，但在老年患者中应谨慎使用。
