Heimdahl A, Nord C E
Eur J Clin Microbiol. 1982 Feb;1(1):38-48. doi: 10.1007/BF02014139.
Erythromycin and clindamycin were given orally to ten subjects in recommended doses for seven days in order to study the effects of these antibiotics on human flora. Saliva and faecal specimens were collected for up to 29 days after administration of the antibiotics. Erythromycin caused only minor changes in the saliva flora while the aerobic and anaerobic colon flora were considerably disturbed. Clindamycin depressed both the anaerobic saliva and colon flora. Both erythromycin and clindamycin induced new colonization of the oral cavity and colon. The levels of free volatile fatty acids sank in saliva and faeces when erythromycin and clindamycin were given. The ecological disturbances caused by antibiotics require further investigation and should be taken into consideration in therapy.
为研究这些抗生素对人体菌群的影响，给10名受试者口服推荐剂量的红霉素和克林霉素，持续7天。在给予抗生素后长达29天内收集唾液和粪便标本。红霉素仅引起唾液菌群的轻微变化，而需氧和厌氧结肠菌群受到相当大的干扰。克林霉素使厌氧唾液和结肠菌群均受到抑制。红霉素和克林霉素均诱导口腔和结肠出现新的定植。给予红霉素和克林霉素时，唾液和粪便中游离挥发性脂肪酸水平下降。抗生素引起的生态紊乱需要进一步研究，在治疗中应予以考虑。
