Pascoe R R
Aust Vet J. 1984 Jul;61(7):231-5. doi: 10.1111/j.1751-0813.1984.tb05997.x.
Twelve medicaments were tested for their efficacy in the treatment of Trichophyton equinum var. autotrophicum; povidone iodine, thiabendazole ointment, captan ointment and Burroughs Wellcome Ringworm Ointment gave satisfactory results but their usefulness may be limited for treatment of large numbers of horses. Aqueous washes containing 0.5% hexetidine or 0.3% chloramine-T did not prevent fungi being isolated from lesions for up to 7 days after treatment. Similarly neither etisazole nor thiabendazole suspension prevented fungi from being isolated from lesions for up to 15 days after treatment. Commonly used aqueous solution of 2.5% lime sulphur and 2% captan were least successful, as fungi could still be isolated from lesions for up to 30 days after treatment. The need to treat large numbers of horses may dictate the use of such solutions rather than ointments because of ease of application and cost factors. Treatments consisting of 10% nystatin ointment, 10% iodine fortis, 10% Medol and a proprietary ointment, Queensland Itch Dressing, were not satisfactory. Clinical appraisal and a scratch test must be used together to evaluate progress of treatment. Mass medication of large numbers of horses should be primarily aimed at reduction of spread of infection; normal hair growth should not be used as an indication of the removal of infective agents in the hair as regrowth was altered very little by medication. Hence assessments of cure on the basis of regrowth of hair alone are of dubious value.
对12种药物治疗马癣菌自养变种的疗效进行了测试；聚维酮碘、噻苯达唑软膏、克菌丹软膏和必治妥癣药膏取得了满意的效果，但它们对大量马匹进行治疗时的实用性可能有限。含有0.5%己脒定或0.3%氯胺-T的水洗液在治疗后长达7天内无法防止从病变部位分离出真菌。同样，益康唑和噻苯达唑悬浮液在治疗后长达15天内也无法防止从病变部位分离出真菌。常用的2.5%石灰硫磺水溶液和2%克菌丹效果最差，因为在治疗后长达30天仍可从病变部位分离出真菌。由于易于应用和成本因素，治疗大量马匹可能需要使用此类溶液而非药膏。由10%制霉菌素软膏、10%强力碘、10%美多洛尔和一种专利药膏昆士兰止痒敷料组成的治疗方法并不令人满意。必须结合临床评估和刮擦试验来评估治疗进展。对大量马匹进行群体用药应主要旨在减少感染传播；不应将正常毛发生长用作毛发中感染因子已被清除的指标，因为用药对毛发生长的改变很小。因此，仅基于毛发生长来评估治愈情况的价值存疑。
