Scuola di Omeopatia Cimi-koinè, Roma, Italy.
Phytomedicine. 2009 Nov;16(11):1056-8. doi: 10.1016/j.phymed.2009.03.013. Epub 2009 Apr 28.
Dermatophytes are a group of keratinophilic and keratinolytic molds, some of which are responsible for ringworm. Among them Trichophyton equinum, which mostly infects equids, can cause extensive outbreaks in stud farms. The conventional treatment of equine trichophytosis is topic, based upon medicated shampoos to reduce the spread of infection among the animals. Nevertheless the popularity of phytotherapy is at an all-time peak, and the interest for natural alternatives or complements to conventional drug therapy is challenging both in human and veterinary field. Among herbal remedia Tea Tree Oil (TTO) shows a wide range of antimicrobial activities. A randomized open clinical trial was carried out on 60 thoroughbred breeding horses affected by equine ringworm. The animals were randomly divided into 2 groups of 30 subjects. Diagnostic criteria were the presence of clinical signs and positive T. equinum culture. Specificity control using TTO mixture in 5 not dermatophyte affected animals was achieved also. The antimycotic activity against T. equinum of a mixture containing 25% TTO in sweet almond oil, was evaluated in vivo treating 30 subjects, the others were administered enilconazole 2% solution. The animals of both groups were topically treated twice a day for 15 days with a 25% mixture of TTO diluted in sweet almond oil and every 3 days, four times with enilconazole rinses, respectively. The clinical and mycological outcome were evaluated at day 30 from the start of the treatments. Data analysis was performed by chi square test. All the treated animals showed complete clinical and aetiological healing. Part of control subjects also, showed an improvement and none of them exacerbate the lesions. This therapeutic protocol appears to be effective and versatile, being applicable immediately after physical examination, prior to have the laboratory response. It could be an alternative for practitioners interested in herbal medicines, contributing to fulfill the gap existing between in vitro and clinical studies.
皮肤真菌是一群角蛋白亲和和角蛋白分解的霉菌，其中一些会导致癣。其中，主要感染马属动物的马毛癣菌（Trichophyton equinum）可在马场引起广泛爆发。马毛癣病的传统治疗方法是局部用药，使用药用洗发水来减少动物之间的感染传播。然而，植物疗法的流行达到了历史最高水平，人们对天然替代品或对传统药物治疗的补充的兴趣在人类和兽医领域都具有挑战性。在草药疗法中，茶树油（TTO）显示出广泛的抗菌活性。在 60 匹受马癣影响的纯种繁殖马中进行了一项随机开放临床试验。这些动物被随机分为两组，每组 30 匹。诊断标准是存在临床症状和阳性的 T. equinum 培养物。在 5 匹未受真菌影响的动物中使用 TTO 混合物也实现了特异性控制。在含有 25%TTO 的甜杏仁油混合物中，评估了抗 T. equinum 的抗真菌活性，30 匹动物接受了治疗，其余动物接受了烯康唑 2%溶液治疗。两组动物均每天两次用 25%TTO 与甜杏仁油的混合物局部治疗 15 天，每 3 天用烯康唑冲洗四次。从治疗开始第 30 天评估临床和真菌学结果。数据分析采用卡方检验。所有接受治疗的动物均表现出完全的临床和病因学愈合。部分对照动物也有改善，没有动物病情恶化。这种治疗方案似乎有效且用途广泛，可在进行体格检查后，在获得实验室反应之前立即使用。对于对草药药物感兴趣的从业者来说，它可能是一种替代方法，有助于弥合体外和临床研究之间的差距。
