α-生育酚和叶绿醌作为视黄酯水解的非竞争性抑制剂。
Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis.
作者信息
Napoli J L, Beck C D
出版信息
Biochem J. 1984 Oct 1;223(1):267-70. doi: 10.1042/bj2230267.
Abstract
Inhibition of rat intestinal retinyl ester hydrolase by alpha-tocopherol (vitamin E) and phylloquinone (vitamin K1) was non-competitive. Maximum inhibition occurred within 10 min, and, particularly with alpha-tocopherol, was substantially reversible. Consequently, increasing tissue concentrations of retinyl esters, which might occur with advancing age or changes in diet, would not diminish the effects of the inhibitors. These data further support the notion that alpha-tocopherol may, at physiological concentrations, influence the concentration of vitamin A and its ester in tissues.
摘要
α-生育酚（维生素E）和叶绿醌（维生素K1）对大鼠肠道视黄酯水解酶的抑制作用是非竞争性的。最大抑制作用在10分钟内出现，尤其是α-生育酚，其抑制作用基本可逆。因此，随着年龄增长或饮食变化可能出现的视黄酯组织浓度增加，不会减弱抑制剂的作用。这些数据进一步支持了这样一种观点，即α-生育酚在生理浓度下可能会影响组织中维生素A及其酯的浓度。
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