Wolff R K, Obminski G, Newhouse M T
Br J Ind Med. 1984 Nov;41(4):499-505. doi: 10.1136/oem.41.4.499.
Nine steel workers participated in controlled exposures to sulphur dioxide alone and sulphur dioxide plus carbon dust (5 ppm and 10 mg/m3, respectively). All were experiencing work related respiratory difficulties. Bronchial clearance was measured using radioaerosol inhalations and external detection. Results were variable and no statistically significant changes were observed. One asthmatic showed a complete cessation of clearance during exposure to sulphur dioxide and carbon dust. Bronchial reactivity was found to be significantly raised after exposure to sulphur dioxide but equivocal results were found after exposure to sulphur dioxide and carbon dust. Pronounced changes in pulmonary function were seen only in the two asthmatic subjects. They could not tolerate the levels, indicating that these threshold limit values are too high, at least for these individuals who showed much greater sensitivity to the pollutants than the others.
九名钢铁工人分别参与了单独接触二氧化硫以及接触二氧化硫加碳尘（分别为5 ppm和10毫克/立方米）的对照实验。他们都有与工作相关的呼吸困难症状。使用放射性气溶胶吸入和外部检测来测量支气管清除率。结果各不相同，未观察到统计学上的显著变化。一名哮喘患者在接触二氧化硫和碳尘期间清除率完全停止。发现接触二氧化硫后支气管反应性显著升高，但接触二氧化硫和碳尘后结果不明确。仅在两名哮喘患者中观察到肺功能有明显变化。他们无法耐受这些水平，表明这些阈限值过高，至少对于那些对污染物表现出比其他人更高敏感性的个体来说是如此。
