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坏死性巩膜炎的显微镜研究。II. 巩膜基质中的胶原蛋白降解

Microscopical studies of necrotising scleritis. II. Collagen degradation in the scleral stroma.

作者信息

Young R D, Watson P G

出版信息

Br J Ophthalmol. 1984 Nov;68(11):781-9. doi: 10.1136/bjo.68.11.781.

DOI:10.1136/bjo.68.11.781
PMID:6498133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1040471/
Abstract

Electron microscopy of tissue excised during surgery in eight cases of advanced anterior necrotising scleritis showed degradation of collagen in the scleral stroma by both intracellular and extracellular mechanisms. In the first of these mechanisms cells resembling active fibroblasts and macrophages were observed in the process of phagocytosis of collagen fibrils into vacuoles associated with dense cytoplasmic granules. In the second mechanism collagen fibrils in large areas of the scleral stroma appeared swollen and unravelled, or completely solubilised, without close association with stromal cells. Both activation and degeneration of stromal fibrocytes were evident in zones of extracellular fibril degradation. These changes appeared to take place prior to invasion of the stroma by cells of the granuloma.

摘要

对8例晚期前部坏死性巩膜炎手术切除组织进行的电子显微镜检查显示，巩膜基质中的胶原蛋白通过细胞内和细胞外机制发生降解。在第一种机制中，观察到类似活跃成纤维细胞和巨噬细胞的细胞在将胶原纤维吞噬到与密集细胞质颗粒相关的液泡中的过程中。在第二种机制中，巩膜基质大片区域的胶原纤维出现肿胀、松散或完全溶解，与基质细胞无紧密关联。在细胞外纤维降解区域，基质纤维细胞的激活和变性均很明显。这些变化似乎发生在肉芽肿细胞侵入基质之前。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/410d49c3186f/brjopthal00155-0034-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/8d43ad9e8512/brjopthal00155-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/8cd27de77d3b/brjopthal00155-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/1291062ba175/brjopthal00155-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/7e4541a15d3f/brjopthal00155-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/46b559893837/brjopthal00155-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/45c65beea961/brjopthal00155-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/88fec339d977/brjopthal00155-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/d126437ffc01/brjopthal00155-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/51efe9d80154/brjopthal00155-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/410d49c3186f/brjopthal00155-0034-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/8d43ad9e8512/brjopthal00155-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/8cd27de77d3b/brjopthal00155-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/1291062ba175/brjopthal00155-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/7e4541a15d3f/brjopthal00155-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/46b559893837/brjopthal00155-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/45c65beea961/brjopthal00155-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/88fec339d977/brjopthal00155-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/d126437ffc01/brjopthal00155-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/51efe9d80154/brjopthal00155-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ca/1040471/410d49c3186f/brjopthal00155-0034-b.jpg

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本文引用的文献

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Br J Ophthalmol. 1952 Jul;36(7):373-84. doi: 10.1136/bjo.36.7.373.
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Doyne Memorial Lecture, 1982. The nature and the treatment of scleral inflammation.多伊恩纪念讲座，1982年。巩膜炎症的性质与治疗。
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用不同强度蓝光和核黄素进行巩膜交联后兔巩膜的超微结构
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