Watson P G, Young R D
Br J Ophthalmol. 1985 Sep;69(9):656-63. doi: 10.1136/bjo.69.9.656.
Anterior segment fluorescein angiography in scleral disease reveals highly characteristic changes in the vasculature of the anterior segment associated with necrotising scleritis. The vaso-obliterative changes discovered in this investigation have been correlated with the histopathology in a patient who had to have tissue replaced. Light and electron microscopy of scleral tissue excised from sites of vascular closure detected by fluorescein angiography peripheral to the scleral defect revealed pathological changes in the absence of inflammatory cell infiltration. These changes included vascular stasis, partial vaso-obliteration, and fibroblastic transformation of scleral fibrocytes in association with intra- and extracellular degradation of the collagenous component of the matrix.
巩膜疾病的眼前节荧光血管造影显示，与坏死性巩膜炎相关的眼前节血管系统有高度特征性变化。本研究中发现的血管闭塞性变化与一名必须进行组织置换患者的组织病理学相关。对荧光血管造影检测到的巩膜缺损周边血管闭合部位切除的巩膜组织进行光镜和电镜检查，结果显示在无炎性细胞浸润的情况下出现了病理变化。这些变化包括血管淤滞、部分血管闭塞，以及巩膜纤维细胞的成纤维细胞转化，同时伴有基质胶原成分的细胞内和细胞外降解。
