帽结合蛋白复合物对兔α珠蛋白mRNA翻译的优先刺激作用。
Preferential stimulation of rabbit alpha globin mRNA translation by a cap-binding protein complex.
作者信息
Sarkar G, Edery I, Gallo R, Sonenberg N
出版信息
Biochim Biophys Acta. 1984 Nov 22;783(2):122-9. doi: 10.1016/0167-4781(84)90003-4.
A cap-binding protein complex (Edery et al. (1983) J. Biol. Chem. 258, 11398-11403) is shown here to stimulate preferentially the translation of endogenous alpha versus beta globin mRNA in a rabbit reticulocyte lysate. Several initiation factors (eIF-2, eIF-3, eIF-4A, eIF-4B, eIF-4C, eIF-4E and eIF-5) and elongation factor 1 were found to have no such discriminatory effect. These results are in contrast to several previous reports and demonstrate that the only factor capable of relieving translational competition between alpha and beta globin mRNAs is the cap-binding protein complex.
本文显示一种帽结合蛋白复合物（埃德里等人，《生物化学杂志》，1983年，第258卷，第11398 - 11403页）在兔网织红细胞裂解物中优先刺激内源性α珠蛋白mRNA而非β珠蛋白mRNA的翻译。发现几种起始因子（eIF - 2、eIF - 3、eIF - 4A、eIF - 4B、eIF - 4C、eIF - 4E和eIF - 5）以及延伸因子1没有这种区分作用。这些结果与先前的几份报告相反，并表明唯一能够缓解α和β珠蛋白mRNA之间翻译竞争的因子是帽结合蛋白复合物。
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