[丁二酸钠对急性降温时代谢及形态学变化的影响]
[Effect of sodium succinate on metabolic and morphological changes in acute cooling].
作者信息
Bobkov Iu G, Kuznetsova G A, Kleĭmenova N N
出版信息
Biull Eksp Biol Med. 1984 Oct;98(10):420-2.
The effect of sodium succinate preinjection (16 mg/kg) on the resistance of mice to acute low-temperature exposure was studied. The measurements were taken of the changes in blood glucose concentration, of the content in the heart of macroergic compounds and glycogen, and of succinate dehydrogenase activity. Cardiomyocytes were studied by electron microscopy. The data indicate that greater preservation of macroergic compounds and stabilization of the ultrastructure of myocardial mitochondria play a role in the mechanism by which the animals' resistance to intense cooling is increased after sodium succinate injection.
研究了预先注射琥珀酸钠（16毫克/千克）对小鼠抵抗急性低温暴露的影响。测量了血糖浓度的变化、心脏中高能化合物和糖原的含量以及琥珀酸脱氢酶的活性。通过电子显微镜研究心肌细胞。数据表明，预先注射琥珀酸钠后，动物对强烈寒冷的抵抗力增强的机制中，高能化合物的更好保存和心肌线粒体超微结构的稳定发挥了作用。
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