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[测定淋巴细胞琥珀酸脱氢酶活性的预后价值及琥珀酸钠在大鼠复苏中的治疗效果]

[Prognostic value of determining the succinate dehydrogenase activity of lymphocytes and the therapeutic effectiveness of sodium succinate in resuscitation of rats].

作者信息

Baranets N A, Dolgikh V T, Nartsissov R P

出版信息

Biull Eksp Biol Med. 1985 Oct;100(10):405-7.

PMID:4052601
Abstract

In the experiments on male rats recovered after clinical death caused by acute hemorrhage and mechanical asphyxia undulatory changes of lymphocyte succinate dehydrogenase activity were revealed: enzyme inhibition during clinical death, activation in the first minutes of resuscitation with subsequent moderate reduction in activity. Lymphocyte succinate dehydrogenase activity was shown to be a reliable prognostic criterion. Pre-injection of sodium succinate at a dose of 20 mg/kg improved considerably the resuscitation results especially during the first two days of rehabilitation period.

摘要

在对因急性出血和机械性窒息导致临床死亡后复苏的雄性大鼠进行的实验中,发现淋巴细胞琥珀酸脱氢酶活性有波动变化:临床死亡期间酶受到抑制,复苏开始后的最初几分钟活性激活,随后活性适度降低。淋巴细胞琥珀酸脱氢酶活性被证明是一个可靠的预后标准。以20毫克/千克的剂量预先注射琥珀酸钠可显著改善复苏结果,尤其是在康复期的前两天。

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