Baĭramkulov Kh D, Gatsura V V
Biull Eksp Biol Med. 1976 Dec;82(12):1439-41.
The influence of sodium succinate on the content of lactic, pyruvic acids and glucose in the venous blood flowing from the ischemic zone of the myocardium was studied in dogs with ligated coronary artery. The intracoronary injection of the preparation in doses of 2 and 10 mg/kg diminished the content of blood lactic acid flowing from the ischemic zone; a dose of 10 mg/kg decreased the consumption of glucose by the ischemic myocardium. Sodium succinate (100 mg/kg) intravenously reduced the content of the lactic acid significantly and inhibited the glucose consumption by the ischemic myocardium, with its increase in the arterial blood. A fall of lactacidemia can be connected with the activation of Krebs cycle and an increase of oxygen utilization by the ischemic myocardium.
在结扎冠状动脉的犬中，研究了琥珀酸钠对从心肌缺血区流出的静脉血中乳酸、丙酮酸和葡萄糖含量的影响。冠状动脉内注射2毫克/千克和10毫克/千克剂量的该制剂可减少从缺血区流出的血液中乳酸的含量；10毫克/千克的剂量可降低缺血心肌对葡萄糖的消耗。静脉注射100毫克/千克的琥珀酸钠可显著降低乳酸含量，并抑制缺血心肌对葡萄糖的消耗，同时动脉血中该物质含量增加。乳酸血症的降低可能与三羧酸循环的激活以及缺血心肌对氧利用的增加有关。
