Grinio L P, Orlov O N, Prilipko L L, Kagan V E
Biull Eksp Biol Med. 1984 Oct;98(10):423-5.
Eighteen patients aged 4 to 13 years with Duchenne's progressive muscular dystrophy were examined for the content of lipid peroxidation (LPO) products (lowest volatile hydrocarbons) in the exhaled air. The level of LPO products was found to exceed normal 4-fold as compared to the control group including healthy children of the same age. The maximal increase was detected at the early stages of the disease with a rapid progressive degeneration. The role of LPO in the pathogenesis of Duchenne's muscular dystrophy and possible applications of free radical oxidation inhibitors as new effective medicinal tools are discussed.
对18名年龄在4至13岁的杜兴氏进行性肌营养不良症患者呼出气体中的脂质过氧化（LPO）产物（最低挥发性碳氢化合物）含量进行了检测。结果发现，与包括同龄健康儿童在内的对照组相比，LPO产物水平超过正常水平4倍。在疾病早期快速进行性变性阶段检测到最大增幅。讨论了LPO在杜兴氏肌营养不良症发病机制中的作用以及自由基氧化抑制剂作为新型有效药物工具的可能应用。
