Hoerni B, Chauvergne J
Bull Cancer. 1984;71(4):297-300.
An induction chemotherapy, before any local treatment, allows to precise the chemosensitivity of the primary tumor. These data may help to improve indication and type of a further adjuvant chemotherapy. However there are many biological differences between different sites of the same tumor and along the time, without or after treatment. It is thus impossible to be sure that a chemotherapeutic regimen effective as first treatment on the primary will be equally active on micro-metastases some months later. Many questions in this field will be answered only by controlled studies and careful observations.
在进行任何局部治疗之前进行诱导化疗，能够明确原发性肿瘤的化疗敏感性。这些数据可能有助于改进后续辅助化疗的适应证和类型。然而，同一肿瘤的不同部位之间以及在治疗前、治疗后不同时间存在许多生物学差异。因此，无法确定对原发性肿瘤作为首次治疗有效的化疗方案在数月后对微转移灶是否同样有效。该领域的许多问题只有通过对照研究和仔细观察才能得到解答。
